We show that this multiplication-like nonlinearity arises from the coincidence of cholinergic excitation and release from glutamatergic inhibition.
Our electrophysiological measurements and conductance-based simulations provide evidence for a passive supralinear interaction between two distinct types of synapse on T4 dendrites. Here we pursue this problem in the Drosophila melanogaster ON motion vision circuit 4, 5, in which we record the membrane potentials of direction-selective T4 neurons and of their columnar input elements 6, 7 in response to visual and pharmacological stimuli in vivo. Nonlinear, multiplication-like operations carried out by individual nerve cells greatly enhance the computational power of a neural system 1, 2, 3, but our understanding of their biophysical implementation is scant.
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